The 10 Best Hyaluronic Acid Serums

Updated October 23, 2017 by Sam Kraft

10 Best Hyaluronic Acid Serums
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We spent 41 hours on research, videography, and editing, to review the top selections for this wiki. As we age, our skin becomes drier as it loses its capacity to retain moisture, which is one of the primary reasons wrinkles and fine lines begin to form. An effective way to combat this process is by integrating hyaluronic acid serum into your skincare routine – helping return elasticity and suppleness by delivering deep hydration and promoting collagen growth. When users buy our independently chosen editorial picks, we may earn commissions to support our work. Skip to the best hyaluronic acid serum on Amazon.

10. OZNaturals Serum

OZNaturals Serum battles wrinkles by balancing moisture levels, thereby permitting new healthy skin to rise to the surface. Say goodbye to dull skin and welcome back a healthy glow with this non-invasive solution tailored to all skin types.
  • natural and fragrance-free
  • short wait time for results
  • thick gel may run out quickly
Brand OZ Naturals
Model IP-I6FX-Z72T
Weight 2.9 ounces
Rating 4.1 / 5.0

9. Vernal Serum

Restoring beauty and youth takes time. With a little patience, you’ll discover that Vernal Serum plumps fine lines, decreases visible sagging, and keeps your skin cells moisturized by continually producing its own natural collagen.
  • features anti-pollution powder
  • no parabens or sulfates
  • occasional tingling sensation
Brand Vernal Skincare
Model pending
Weight 3.2 ounces
Rating 3.6 / 5.0

8. Cosmedica Skincare

Tired of dealing with oily skin, puffiness and uneven tone? Cosmedica Skincare is a highly popular choice for a reason, effectively addressing all of these conditions and more. Blend it with your favorite moisturizer to enhance results.
  • gentle on sensitive skin
  • no dyes or fillers
  • thinner than many other serums
Brand Cosmedica Skincare
Model pending
Weight 4 ounces
Rating 3.9 / 5.0

7. InstaNatural Youthful & Radiant

For an intense hydration experience that delivers speedy relief to your driest patches, opt for the InstaNatural Youthful & Radiant. Thanks to support from green tea, jojoba oil and extra vitamins, you’ll notice positive skin renewal changes each time you check the mirror.
  • special fast-absorbing formula
  • works comfortably under makeup
  • applies evenly and effortlessly
Brand InstaNatural
Model INS011301000060
Weight 2.9 ounces
Rating 3.7 / 5.0

6. Timeless Original

Friendly to your budget and even friendlier to your skin, the Timeless Original achieves results without irritation or leaving you feeling greasy – proof that, in many cases, keeping it simple is the best recipe for success.
  • fewer chemicals than most serums
  • absorbs swiftly and naturally
  • dries fast and clear
Brand Timeless Skin Care
Model HAP-2
Weight 4 ounces
Rating 3.9 / 5.0

5. Vernal Acid Pure

The Vernal Acid Pure offers a smooth consistency – balanced between a liquid and a gel – that makes it a pleasure to apply. As effective for men as it is for women, anyone yearning for smoother, healthier skin can benefit from this serum.
  • makes pores less visible
  • high value at affordable price
  • diminishes redness efficiently
Brand Vernal Acid Pure
Model NA
Weight 4.8 ounces
Rating 4.3 / 5.0

4. VoilaVe Advanced

The VoilaVe Advanced uses a unique formula with distinct molecular weights of hyaluronic acid. Because of this, it penetrates both the dermis and epidermis of your skin, generating more moisture retention than other serums to leave you feeling ultra-nourished.
  • adept at removing cell impurities
  • never tested on animals
  • ingredients are directly sourced
Brand VoilaVe
Model Voila-hya1
Weight 2.4 ounces
Rating 4.3 / 5.0

3. Body Merry

Apply, replenish and be merry with the Body Merry, a perfectly-blended anti-aging solution that ensures your face maintains the dewy feel you love. As an added benefit, it’s formulated to protect your skin from harmful outside elements as well.
  • easily removes bags under eyes
  • lightweight yet powerful
  • useful for all ages
Brand Body Merry
Model pending
Weight 3 ounces
Rating 5.0 / 5.0

2. YEOUTH All Natural

Turn back the clock with the YEOUTH All Natural, which is designed to act as a non-surgical wrinkle remover that helps you prolong – or relive – the days of your youth. It’s made with medical-grade ingredients, so prepare to look radiant and full of life.
  • made of vegan components
  • leaves no rawness or discomfort
  • 100 percent satisfaction guarantee
Brand Yeouth
Model pending
Weight 4.8 ounces
Rating 4.8 / 5.0

1. Joyal Beauty

The Joyal Beauty stands out in a crowded market as the only pure hyaluronic acid serum concentrated at four percent and derived from organic vegetables. It’s truly natural, completely chemical-free and suitable for the most hypersensitive skin.
  • superior absorption
  • produces visibly plumper skin
  • long-lasting reliability
Brand Joyal Beauty
Model HAS1
Weight 0.8 ounces
Rating 4.7 / 5.0

How Does Hyaluronic Acid Serum Help The Skin?

Healthy hyaluronic acid had a rather humble start. A patent from 1942 shows that hyaluronic acid was actually intended to be a replacement for egg whites in recipes. After the initial discovery of the characteristics of hyaluronic acid, many companies started researching the other potential benefits this substance could have. It turned out that hyaluronic acid is found many places in the natural world, including foods, animals, and humans themselves.

The human body creates hyaluronic acid naturally. The problem is that this supply of hyaluronic acid does not stay the same over time. As humans age, their bodies tend to produce less hyaluronic acid. Less hyaluronic acid means less moisture in the skin, which directly contributes to age lines, wrinkles, sun spots, and other skin conditions, like rosacea.

The reason hyaluronic acid has such a drastic effect on the skin is because of how it protects the skin from damage. Hyaluronic acid easily bonds to liquids like water, which then help fill out the skin and protect its elasticity. This excess moisture can also absorb the damage caused by pollution, light exposure, or toxins — all of which directly lead to unhealthy skin.

Hyaluronic acid serum is not the only treatment method required for youthful skin. Other factors like nutrition also play a big role in skin aging. Healthy food choices protect the skin, where unhealthy food choices may actually damage the skin. Hyaluronic acid is just one part of the recipe for vibrant skin; right alongside healthy eating, cleansing and exfoliation, and proper sleep. Every dietary and lifestyle choice combines to shape the healthiest skin possible.

Other Benefits Of Hyaluronic Acid Sera

Using a hyaluronic acid serum topically is one way to get more hyaluronic acid into the body, and its benefits to the surface of the skin are apparent. Yet there are a few more astounding ways hyaluronic acid and hyaluronic acid sera affect the body.

Hyaluronic acid is also heavily marketed as a solution for joint pain caused by deterioration. Aging bodies or jobs that put a lot of stress on the joints can lead to chronic conditions like osteoarthritis. The body cannot keep up with this excess stress, which causes the joint to become worn down and damaged over time. This can cause symptoms of inflammation, pain, and disability in the affected joints. Knee osteoarthritis is the most common, and is often managed through weight loss, stress management, knee braces, and physical routines. Doctors will often inject steroids into the knee to alleviate symptoms. Researchers recently found that hyaluronic acid is an even better long term treatment option than steroids for people with knee osteoarthritis.

Some people choose to rub hyaluronic acid sera and creams directly on the joints. These people either do not like the way hyaluronic acid makes them feel when they take it internally or respond poorly to knee injections containing hyaluronic acid. Researchers need to do more extensive studies to see just how deep into the joints a topical application can go, but anecdotal evidence is good enough for some.

Hyaluronic acid is also an invaluable tool for many eye issues. Some surgeons use hyaluronic acid during eye surgeries to help replace natural eye fluids and protect the eye from further damage. The FDA has even approved hyaluronic acid for use during eye surgeries such as corneal transplants and cataract removal.

Hyaluronic acid also makes a better filler than collagen or fat in plastic surgery. People looking for plump, soft lips often get hyaluronic acid injected into their lips. The results are full lips with less bruising and bumps than other fillers. Lips filled with hyaluronic acid keep their fullness for about six months, but the results are not permanent, which is good in case the patient changes their mind. People are also much less likely to have an allergic reaction to hyaluronic acid when compared to other fillers.

How Is Hyaluronic Acid Made?

Hyaluronic acid is a natural substance in the human body. The umbilical cord has the highest concentration of hyaluronic acid in fetuses. In adults, hyaluronic acid is found in the fluid that fills the joints and spinal column, as well as the fluid of the eyes. Hyaluronic acid is also found in every bone in the entire body, though to a lesser extent than in the joints. The body produces this compound by breaking down foods that contain high amounts of it — often root vegetables like potatoes, parsnips, and carrots. The average person has about 17 to 20 grams of hyaluronic acid floating around in their body at any given point. Fortunately, the hyaluronic acid we use is not taken from humans. The hyaluronic acid in most serums is easily produced using natural sources.

Creating the hyaluronan that makes up hyaluronic acid is a two part process. First, manufacturers extract hyaluronan from a natural source. This is simple enough, as the compound is found in all vertebrates and many vegetables. The problem manufacturers face is degrading quality, as enzymes constantly seek to break down the hyaluronan. A simple extraction often delivers a low yield, even with the highest quality source. The other problem manufacturers face is contamination from toxins, like viruses and unwanted proteins.

The answer to these problems sparked the boom in the use of hyaluronic acid. Manufacturers now use a fermentation process to ensure their hyaluronic acid is of the highest quality. Early on, researchers found many different bacterial strains that could help hyaluronan multiply. Of all these strains, it was Streptococcus zooepidemicus that became the standard. Manufacturers add the bacteria to the hyaluronan and culture it until the hyaluronic acid produced is at the exact specifications needed. Controlled laboratory environments help prevent contamination and the proliferation of any toxins or pathogenic bacteria.

Many promising new microbes have recently appeared in the field, as well. These include strains like Bacillus sp., L. lactis, Agrobacterium sp., and even an engineered strain of E. coli. These strains help to increase the yield and further reduce the chances that harmful germs will infect the hyaluronic acid. After fermentation is complete, the resulting product is added to hyaluronic acid serums and other products as needed.



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Last updated on October 23, 2017 by Sam Kraft

Sam is a marketing/communications professional and freelance writer who resides in Chicago, IL and is perpetually celebrating the Cubs’ 2016 World Series victory.


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